abstract：:A kinetic study of the cells present in the spleen of BALB/c mice infected with Schistosoma mansoni was carried out. The lymphocytes were evaluated phenotypically with monoclonal antibodies and the effect of splenectomy on the modulation of periovular granuloma was also investigated. The infected mice had proportional...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Arruda SM,Santoro F,Sadigursky M

更新日期：1993-01-01 00:00:00

abstract：:Ketoconazole, an azole antifungic drug which is already in the market has also been demonstrated to be active against Trypanosoma cruzi experimental infections. In this paper we confirmed the drug effect and investigated its range of activity against different T. cruzi strains naturally resistant or susceptible to bot...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Brener Z,Cançado JR,Galvão LM,da Luz ZM,Filardi Lde S,Pereira ME,Santos LM,Cançado CB

更新日期：1993-01-01 00:00:00

abstract：:A cross-sectional study for schistosomiasis was carried out in the localities of Aliança, Alegre and Coroatá (districts of Cururupu, São Bento and São João Batista, respectively) in the lowland of the state of Maranhão, after respectively 13, 11 and 4 mass treatments with oxamniquine in the period of ten years (1977-1...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Cutrim RN,Coura JR

更新日期：1992-10-01 00:00:00

abstract：:Details are given of the prevalence rates of onchocerciasis from the most recent surveys (1989) conducted in northern Ecuador. The disease has intensified and dispersed considerably due to migration of infected individuals and the presence of a highly efficient vector. Comparison of these data with those from two prev...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Guderian RH,Shelley AJ

更新日期：1992-07-01 00:00:00

abstract：:The present report describes an alternative method for in vitro detection of HIV-1-specific antibody secretion in 24h of culture employing as stimulant of peripheral blood mononuclear cells the disrupted inactivated whole virus adsorbed onto microwells in a commercial ELISA kit plates. The results obtained from this t...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Caterino-de-Araujo A

更新日期：1992-04-01 00:00:00

abstract：:Immunoblot analysis was used to investigate antigenic differences among clinical isolates of Leishmania amazonensis and their role in the etiology of the disease. Western blots of promastigote homogenates were analyzed with either monoclonal antibodies (MAbs) specific for the L. mexicana complex (M-4, M-6, M-9, and M-...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Leon LL,Machado GM,Barral A,de Carvalho-Paes LE,Grimaldi Júnior G

更新日期：1992-04-01 00:00:00

abstract：:In the Saimiri monkey, an experimental host for human malaria, acquired protection against Plasmodium falciparum blood stages depends on the IgG antibody populations developed. In vivo protective anti-falciparum activity of IgG antibodies is correlated with the in vitro opsonizing activity promoting phagocytosis of pa...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Gysin J

更新日期：1992-01-01 00:00:00

abstract：:This review presents up-to-date information on the distribution and control measures of babesiosis in Latin America. Bovine babesiosis caused by Babesia bovis and B. bigemia will be emphasized. The disease is endemic in most countries and poses a serious economic burden on livestock production in the region (U.S. $136...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Montenegro-James S

更新日期：1992-01-01 00:00:00

abstract：:The diagnosis of tick-borne diseases such as babesiosis still depends on observing the parasite in the infected erythrocyte. Microscopic observation is tedious and often problematic in both early and carrier infections. Better diagnostic methods are needed to prevent clinical disease, especially when susceptible cattl...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Wagner G,Cruz D,Holman P,Waghela S,Perrone J,Shompole S,Rurangirwa F

更新日期：1992-01-01 00:00:00

abstract：:The Kilombero Malaria Project (KMP) attempts to define operationally useful indicators of levels of transmission and disease and health system relevant monitoring indicators to evaluate the impact of disease control at the community or health facility level. The KMP is a longitudinal community based study (N = 1024) i...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Teuscher T

更新日期：1992-01-01 00:00:00

abstract：:The thymus is a central lymphoid organ, in which T cell precursors differentiate and generate most of the so-called T cell repertoire. Along with a variety of acute infectious diseases, we and others determined important changes in both microenvironmental and lymphoid compartments of the organ. For example, one major ...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Savino W,de Moraes Mdo C,Barbosa SD,Da Fonseca EC,De Almeida VC,Hontebeyrie-Joscowicz M

更新日期：1992-01-01 00:00:00

abstract：:The determination of amino acid changes in the envelope protein by direct sequencing of either genomic RNA or PCR-amplified cDNA fragments provides useful informations for assessing the genetic variability and the geographic distribution of the actually most widespread dengue-2 serotype. The possible link of variation...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Deubel V

更新日期：1992-01-01 00:00:00

abstract：:We characterized the Plasmodium falciparum antigen 332 (Ag332) which is specifically expressed during the asexual intraerythrocytic cycle of the parasite. The corresponding Pf332 gene has been located in the subtelomeric region of chromosome 11. Furthermore, it is present in all strains so far analyzed and shows marke...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Mattei D,Scherf A

更新日期：1992-01-01 00:00:00

abstract：:Catadiscus pomaceae sp. n. from the intestine of the prosobranch mollusc Pomacea canaliculata (Lamarck, 1801), is described. The host snail was collected from a lenitic biotope belonging to the Riachuelo basin (Corrientes province, Argentina) during 1985-1986. So far the species of the genus Catadiscus Cohn, 1904 have...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Hamann MI

更新日期：1992-01-01 00:00:00

abstract：:Cytokines are important in the cell-mediated response to Schistosoma mansoni eggs. We have found that Th2 cytokine responses (e.g. IL-4 and IL-5) are augmented after egg laying begins while Th1 responses (IL-2 and IFN-gamma) are down regulated in S. mansoni infected mice. Treatment of mice with anti-IL-5 monoclonal an...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Cheever AW,Xu Y,Macedonia JG,Cox T,Hieny S,Sher A

更新日期：1992-01-01 00:00:00

abstract：:In this paper a discussion is made on the pathogenesis of schistosomiasis mansoni in mice, presented from the perspectives of "processes", "mediators", "strategies for study" and "disease". These concepts overlap considerably. Regarding "processes", granulomas, fibrosis and vasculitis are discussed. The role of mediat...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Cheever AW

更新日期：1992-01-01 00:00:00

abstract：:Facilitated and improved by advances in molecular biology, techniques for the immunodiagnosis of schistosomiasis, including assays based on the detection of antigens circulating in the serum and/or excreted in the urine, have now reached the stage of multi-centre trials. There is a need to complement parasitological t...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Bergquist NR

更新日期：1992-01-01 00:00:00

abstract：:Schistosomiasis in America with the exception of Brazil, behaves as a chronic mild disease with few clinical manifestations due to low parasite burden. These features restrict the clinical and parasitological diagnosis. The most commonly used stool examination method, Kato-Katz, becomes insensitive when the majority o...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： de Noya BA,Noya O,Balzan C,Cesari IM

更新日期：1992-01-01 00:00:00

abstract：:After the acute hyperergic phase of schistosomal infection, the chronic phase of the disease corresponds to the establishment of a relative equilibrium between the host and the parasite. This involves: (1) A shift from the predominance of the TH2 response observed in the acute phase, to the predominance of the TH1 res...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Borojevic R

更新日期：1992-01-01 00:00:00

abstract：:In C57Bl/6 strain mice vaccinated with radiation-attenuated cercariae of Schistosoma mansoni immune elimination of challenge parasites occurs in the lungs. Leucocytes were recovered from the lungs of such mice by bronchoalveolar lavage and cultured in vitro with larval antigen; the profile of cytokines released was th...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Wilson RA

更新日期：1992-01-01 00:00:00

abstract：:A new species of the genus Cotylophoron (Trematoda--Paramphistomidae) --Cotylophoron travassosi sp. n.--is described. The measurements of the worm and its structures are compared with the valid known species. ...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Costa HM,Guimaráes MP

更新日期：1992-01-01 00:00:00

abstract：:Some species of Amphibia and Reptilia are listed as new hosts of spargana, from material deposited in the Helminthological Collection of Oswaldo Cruz Institute. It is discussed the difficulties in identifying the larvae (Sparganum) and also the identification of adults of Luheella species from South America. The histo...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Rego AA,Schäffer GV

更新日期：1992-01-01 00:00:00

abstract：:Many lines of Plasmodium falciparum undergo a deletion of the right end of chromosome 9 during in vitro culture accompanied by loss of cytoadherence and gametocytogenesis. Selection of cytoadherent cells from a mixed population co-selects for those with an undeleted chromosome 9 and the selected cells produce gametocy...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Kemp DJ,Thompson J,Barnes DA,Triglia T,Karamalis F,Petersen C,Brown GV,Day KP

更新日期：1992-01-01 00:00:00

abstract：:The effect of deltamethrin of the sandfly population in a focus of American Cutaneous Leishmaniasis in Viana, Espírito Santo State is described. The phlebotomine population density was determined inside and outside houses during a one year period in a treated and untreated area. The results showed a significant reduct...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Falcão AL,Falcão AR,Pinto CT,Gontijo CM,Falqueto A

更新日期：1991-10-01 00:00:00

abstract：:The authors investigated the distribution of lectin receptors on Trypanosoma cruzi blood forms collected from mice inoculated with, respectively, the drug-resistant and drug-sensitive strains VL-10 and CL, and treated with the two standard active nitroheterocyclic compounds nifurtimox and benznidazole used for treatme...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Fontes G,Romanha AJ,Pereira ME,Brener Z

更新日期：1991-07-01 00:00:00

abstract：:A large bibliographic survey provided data on Trypanosoma cruzi serology covering the period 1948-1984. Epidemiological-demographic methods provided an estimate of 11% for the prevalence of positive serology in Brazil, by 1984. Significant temporal trends were observed for most of the Brazilian geographical regions as...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Feitosa MF,Krieger H

更新日期：1991-04-01 00:00:00

abstract：:Genomic DNA fragments from males of Psychodopygus wellcomei were isolated and shown to be useful as sensitive diagnostic probes for positively separating individuals of this species from those of Ps. complexus. These two members of the Ps. squamiventris series are found sympatrically in foci of cutaneous leishmaniasis...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Ready PD,Lainson R,Shaw JJ,Souza AA

更新日期：1991-01-01 00:00:00

abstract：:The objective of this work was to characterize, and compare different morphological types of hemocytes of Rhodnius prolixus, Rhodnius robustus, Rhodnius neglectus, Triatoma infestans, Panstrongylus megistus, and Dipetalogaster maximus. This information provides the basis for studying the cellular immune systems of the...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： de Azambuja P,Garcia ES,Ratcliffe NA

更新日期：1991-01-01 00:00:00

abstract：:Toxicological and toxicogenetic effects of aqueous (tea) and hexanic fruit extract of Indigofera suffruticosa Mill. and hydroalcoholic root extract of Solanum agrarium Stendt. were evaluated in Balb C male mice intraperitoneally exposed. A hepatotoxic effect was observed just for animals treated with aqueous fruit ext...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Ribeiro LR,Bautista AR,Silva AR,Sales LA,Salvadori DM,Maia PC

更新日期：1991-01-01 00:00:00

abstract：:A rational method of search for natural neolignans of desired structures is outlined. This involves consultation of a collection of chemical profiles of plant families. The profiles are assembled considering the biosynthetic class (in the present case lignoids), subclass (neolignans), structural types (neolignan skele...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Gottlieb OR

更新日期：1991-01-01 00:00:00

abstract：:Osteoarthritis (OA) is a common painful inflammatory condition occurring mainly in the later half of life. Hip and knee are the joints mostly affected. Petiveria alliacea (tipi) popularly known as an anti-rheumatic medicine, has been used by OA patients to relief pain. This one-week cross-over double-blind trial has p...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Ferraz MB,Pereira RB,Coelho Andrade LE,Atra E

更新日期：1991-01-01 00:00:00

abstract：:Small molecular weight compounds from Mandevilla velutina and from Eclipta prostata were found to be active against snakebite. ...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Mors WB

更新日期：1991-01-01 00:00:00

abstract：:Analgesic and anti-inflammatory activities of water (WE) and ethanolic (EE) extracts of Scoparia dulcis L. were investigated in rats and mice, and compared to the effects induced by Glutinol, a triterpene isolated by purification of EE. Oral administration (p.o.) of either WE or EE (up to 2 g/kg) did not alter the nor...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Freire SM,Torres LM,Roque NF,Souccar C,Lapa AJ

更新日期：1991-01-01 00:00:00

abstract：:A preliminary study of the pharmacokinetic parameters of t-Butylaminoethanethiol (TBAESH) was performed after administration of a single dose (35 mg/kg) either orally or intravenously. Plasma or blood samples were treated with dithiothreitol, perchloric acid and, after filtration, submitted to further purification wit...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Andrade MH,Freire AC,Nelson DL

更新日期：1990-07-01 00:00:00

abstract：:Rhesus monkeys (Macaca mulatta) were infected subcutaneously with 1.0 x 10(4) to 1.5 x 10(4) metacyclic trypomastigotes of Trypanosoma cruzi (Colombian strain). Parasitological and immunological parameters were evaluated in these animals for periods of 1 month to over 3 years. A chagoma was observed between the 3rd an...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Bonecini-Almeida Mda G,Galvão-Castro B,Pessoa MH,Pirmez C,Laranja F

更新日期：1990-04-01 00:00:00

abstract：:Forty-three (31.4%) out of 137 serum samples obtained from two Indian communities living in the Amazon region were found to be positive for HTLV-I antibody, as tested by enzyme-linked immunosorbent assay (ELISA). Eighty-two sera were collected from Mekranoiti Indians, yielding 39% of positivity, whereas 11 (20.0%) of ...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Nakauchi CM,Linhares AC,Maruyama K,Kanzaki LI,Macedo JE,Azevedo VN,Casseb JS

更新日期：1990-01-01 00:00:00

abstract：:Three Yersinia pestis strains isolated from humans and one laboratory strain (EV76) were grown in rich media at 28 degrees C and 37 degrees C and their outer membrane protein composition compared by sodium dodecyl sulphate polyacrylamide gel electrophoresis (SDS-PAGE). Several proteins with molecular weights ranging f...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Abath FG,de Almeida AM,Ferreira LC

更新日期：1990-01-01 00:00:00

abstract：:Tissue parasitism, inflammatory process (histologic methods) and sympathetic denervation (glyoxylic acid-induced histofluorescence for demonstration of catecholamines) were studied in the heart (atrium and ventricle) and the submandibular gland of rats infected with the Y strain of Trypanosoma cruzi. In the heart para...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Machado CR,Ribeiro AL

更新日期：1989-10-01 00:00:00

abstract：:Current strategies for schistosomiasis control rely heavily on drug treatment intended to reduce morbidity and disease to an insignificant level of public health importance. This approach reduces but rarely, if ever, eliminates transmission. Indeed, snail infection rates may be little altered by such chemotherapy. Rei...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Sturrock RF

更新日期：1989-10-01 00:00:00

abstract：:The aim of the current paper was to study in the state of Sergipe the population distribution and interactions between two species of Biomphalaria, the snail vectors of Schistosoma mansoni in the northeastern Brazil. Data collected in 1969 showed that B. straminea, with only one exception, was limited to the semi-dry ...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Figueiredo CC

更新日期：1989-07-01 00:00:00